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KMID : 0378019890320090030
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New Medical Journal
1989 Volume.32 No. 9 p.30 ~ p.36
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Clinical Effect of Nimodipine in Patients Organic Brain Syndrome
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Abstract
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In order to investigate the effects of a Ca-antagonist nimodipine in patients with organic brain syndrome, non-controlled clinical trial was done for the 30 cases of patients.
Nimodipine had been orally administrated to the patients during the 12-week treatment period.
A significantly better neurologic outcome, as assessed by the Sandoz Clinical Assessment
-Geriatric(SCAG) scale of neurologic deficit, was observed at the end of 12-week treatment compared with the initial status before treatment by nimodipine.
The global assessment of the 12-week therapeutic effects of nimodipine was revealed to the relatively good improvements by the physicians who were participated in this study.
During the administration of nimodipine, the results from the hematology and blood chemistry for each patients were not significantly changed within their normal ranges, and there were no important side effects that may have been related to the nimodipine therapy.
Our data suggest that patients with organic brain syndrome may benifit, especially for the neurologic recovery, from the treatment of nimodipine.
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